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Alterations in three genes, linked to the development of preeclampsia
A team of researchers from the University of Washington, United States, has identified genetic alterations in autoimmune diseases that increase the risk of preeclampsia, a circumstance that occurs in 10 percent of births.
DM - Wednesday March 23, 2011 - Updated at 00:00 pm
The team of John P. Atkinson has also located these mutations in women with preeclampsia who do not have underlying autoimmune diseases.
As published in the latest issue of PLoS Medicine, these findings provide genetic targets for the arrival of new treatments, and suggest that screening could eventually identify women at risk. The work has been performed with groups from the Universities of Newcastle (England) and Utah (United States) and the Georges Pompidou Hospital, Paris (France). Mutations
Researchers studied 250 pregnant women affected lupus and antiphospholipid antibody syndrome. 30 percent developed preeclampsia during the study, while another 10 percent, which also developed the disease and had suffered in previous pregnancies.
In these forty women were studied three genes related to immune response against infections (MCP, factor I and factor H). Seven of the women had abnormalities in at least one of these genes. Atkinson has focused on these three genes and their association with a rare hemolytic uremic syndrome.
alterations in three genes, linked to the development of preeclampsia - DiarioMedico.com
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