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SPAIN
study 'protect', mcmaster university
Dalteparin no better than unfractionated heparin in DVT
critical study published today The New England Journal of Medicine showed that dalteparin is no better than unfractionated heparin to reduce the incidence of proximal deep vein thrombosis in patients admitted to intensive care units. The rate of bleeding, mortality and hospital admission is similar.
Writing - Wednesday, March 23, 2011 - Updated at 00:00 pm
In critically ill patients, dalteparin is not superior to unfractionated heparin in reducing the incidence of proximal deep vein thrombosis, a study has advanced the publication The New England Journal of Medicine.
Protect The study, coordinated by Deborah Cook, McMaster University, Canada, is designed to assess the superiority of dalteparin over unfractionated heparin. Were selected randomly to receive dalteparin 3,764 patients at a dose of 5,000 IU once daily plus placebo or unfractionated heparin at a dose of 5,000 IU twice daily throughout their stay in the ICU.
The primary endpoint was thrombosis proximal DVT was diagnosed by ecosonography that took place two days after admission, twice a week and when it was indicated by the clinic. The data were analyzed according to intention to treat principle.
The proportion of patients with pulmonary embolism was lower in the dalteparin group compared with unfractionated heparin
There were no significant differences between the two groups in the rate of proximal deep vein thrombosis, which originated in 96 of 1,873 patients receiving dalteparin compared to 109 of the 1,873 in the group receiving unfractionated heparin.
The proportion of patients pulmonary embolism was significantly lower in the dalteparin group when compared with unfractionated heparin.
There were also no differences in bleeding rates or mortality during hospitalization.
In prespecified analysis for the protocols, the results were similar to the main analysis, but a group of patients who received dalteparin had heparin-induced thrombocytopenia.
(N Engl J Med, DOI: 10.1056/NEJMoa1014475).
Dalteparin no better than unfractionated heparin critical TVP - DiarioMedico.com
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