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NEUROLOGY
Melatonin may help prevent Parkinson
JANO.es · March 23, 2011 12:08

. Scientists from Granada have found in mice than other similar substances, which act as specific antagonists of nNOS and iNOS isoforms also have an important protective role against oxidative damage and inflammatory. Scientists


Biomedical Research Center (CIBM), University of Granada have found, using a mouse study, the consumption of melatonin, natural molecule synthesized by virtually all living things, can help prevent the onset Parkinson's, and that is a potent antioxidant and anti-inflammatory agent.

This work also confirmed that other substances similar to melatonin, which act as specific antagonists of nNOS and iNOS isoforms also have an important protective role against oxidative damage and inflammatory as well as against the recovery of complex I activity, the inhibition is a fundamental pathophysiological event in the development of Parkinson's.

According to officials of labor, these data may be to design new drugs that help prevent disease. In fact, even today the cause is unknown primary dopaminergic degeneration in Parkinson's disease, with existing treatments for type mainly symptomatic.

This Research has now tried to explain the role of nitric oxide (NO) in oxidative stress, inflammation and mitochondrial dysfunction in the origin of this disease in a mouse model treated with a toxin that mimics the biochemical and symptoms of disease even in humans (called MPTP).

As the researchers note, the neuroprotective drug development has slowed due to the limited knowledge of the actual mechanisms by which dopaminergic neurons die.

Thus, if melatonin treatment significantly reduced the activity of the iNOS / i-mtNOS (cytosolic and mitochondrial), decreasing Mitochondrial oxidative damage, the search of synthetic compounds similar to melatonin could provide new pharmacological tools with greater selectivity for inhibiting iNOS / i-mtNOS, and capable of being used in the clinic.

Parkinson's disease is a 40% reduction in the activity of complex I of the electron transport chain in the substantia nigra of these patients, with a loss of between 70 and 80% of the neurons located in this tissue before symptoms appear.

In mice treated with MPTP for this study, the activity of complex I is reduced by 65% \u200b\u200bin the substantia nigra, and treatment with melatonin or its structural analogues counteract this reduction, normalizing mitochondrial function.

has also been shown that excess nitric oxide in the substantia nigra, following MPTP administration is due to increased iNOS activity and i-mtNOS by 250%, while the constitutive nNOS activity remains virtually unchanged. Thus, iNOS-deficient mice and not lacking nNOS are protected.

Biomedical Research Centre University of Granada
> Biomedical Research Center.

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