Diariomedico.com
SPAIN AFTER grown in the laboratory, was grafted onto mice with no germs
intestinal microbiota is personal, but 'transferable'
intestinal microbiota can be grown in the laboratory and because it is unique to each individual could be helpful to establish common features of a type of diet or illness. It has also been shown to be transferred to another intestinal tract.
Writing - Wednesday, March 23, 2011 - Updated at 00:00 pm
The laboratory of Jeffrey I. Gordon, in the Science Center Genomic and Systems Biology at Washington University in St. Louis, has shown that you can manipulate the intestinal microbiota in each subject in order to improve certain diseases. The research, published in the online edition of Proceedings of the National Academy of Sciences, provides the basis for identifying microorganisms that, when grafted onto the intestinal flora of an individual, could benefit the community of microorganisms sick.
After years of research have been able to culture bacteria from the organism in the laboratory, but until this work had not been able to determine whether the collection of organisms caught in a Petri dish was just which populated the gut. "There are many types of bacteria in different parts of the human body and also differ between one person and another," said Gordon, whose team has finally achieved using the latest DNA sequencing technologies.
From the samples of two unrelated individuals, the scientists identified a gene present in all organisms. This gene acts as a kind of common barcode an entire microbial community. Thus, each subject found that accounted for a specific collection of microorganisms, grown in the laboratory. Scientists transplanted
microbial collections, some cultivated and others not in the intestinal tracts of germ-free mice. The library adopted the grafted animals and mimicked the donated microbiota.
By studying in detail the mice, it was found that communities of microbes from the same human donor behaved similarly when the animal changed the diet to use (based on vegetables) to the typical Western diet (rich in fat and carbohydrates). The changes were identical, whether the samples had been grown or not.
According to Gordon, this work is the first step toward obtaining custom collection of gut microbes in response diets or diseases.
(PNAS DOI: 10.1073 / pnas.1102938108). Jeffrey I.
Gordon Gordon's group, common in scientific journals, was the first to establish the possible relationship between obesity and other eating disorders and the microbiota that inhabit the human gut. Another of his most famous family revealed a common nexus of intestinal microbial community (see DM of 1-XII-2008).
BILLION PEOPLE
In the gut of every human being lives a unique collection of trillions of microbes that help digest what you eat. The normal thing is to maintain a healthy symbiotic relationship with these small residents, although there are concerns about deterioration in the microbiota may have some influence on the emergence of obesity, malnutrition, Crohn's disease and other disorders. Works such as Jeffrey I. Gordon come to answer the question of how this relationship influences the disease and, more specifically, to what extent the nutritional status of an individual can refer to their gut microbes. These inquiries are raised with the goal on the horizon, to develop therapeutic interventions based on manipulation of the microbiota.
The intestinal microbiota is personal, but 'transferable' - DiarioMedico.com
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